Michele Vendruscolo Selected Research

peptide A

1/2021	Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis.
10/2015	The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments.

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Michele Vendruscolo Research Topics

Disease

53	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 06/2007
42	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 07/2005
39	Parkinson Disease (Parkinson's Disease) 10/2021 - 01/2005
11	Proteostasis Deficiencies 01/2022 - 12/2011
6	Neuroblastoma 01/2021 - 01/2017
6	Amyloid Plaque 11/2020 - 01/2016
4	Dementia (Dementias) 01/2021 - 04/2013
3	Amyloidosis 01/2020 - 04/2011
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 01/2017
2	Tauopathies 12/2021 - 01/2015
2	Synucleinopathies 10/2021 - 01/2021
2	Nervous System Diseases (Neurological Disorders) 01/2021 - 09/2007
2	Paralysis (Palsy) 01/2018 - 01/2017
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Chronic Traumatic Encephalopathy 01/2020
1	Multiple System Atrophy 01/2020
1	Cardiotoxicity 01/2020
1	Huntington Disease (Huntington's Disease) 01/2020
1	Pick Disease of the Brain (Pick's Disease) 01/2020
1	Muscular Diseases (Myopathy) 12/2019
1	Sporadic Creutzfeldt-Jakob Disease 11/2019
1	Chronic Wasting Disease 11/2019
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 11/2019
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2018
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2018
1	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2017
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2015
1	Friedreich Ataxia (Friedreich's Ataxia) 09/2014
1	Neoplasm Metastasis (Metastasis) 06/2014
1	Brain Diseases (Brain Disorder) 10/2011
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2011
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 12/2009

Drug/Important Bio-Agent (IBA)

58	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2005
48	Amyloid (Amyloid Fibrils)IBA 10/2021 - 10/2007
37	Peptides (Polypeptides)IBA 01/2022 - 07/2005
35	SynucleinsIBA 10/2021 - 08/2011
12	Intrinsically Disordered ProteinsIBA 01/2022 - 01/2005
9	Pharmaceutical PreparationsIBA 01/2021 - 08/2011
6	LipidsIBA 01/2022 - 01/2017
4	24-dihydroxy-5-cholestane 24-sulfate 3-N-1(spermine)-7IBA 01/2022 - 01/2018
4	Amyloid beta-PeptidesIBA 01/2021 - 04/2010
4	alpha-SynucleinIBA 09/2009 - 01/2005
3	Molecular Chaperones (Chaperone, Molecular)IBA 01/2021 - 10/2015
3	AntibodiesIBA 12/2019 - 01/2017
2	ProteomeIBA 01/2022 - 01/2020
2	squalamineIBA 01/2022 - 01/2017
2	tau Proteins (tau Protein)IBA 12/2021 - 11/2017
2	Single-Domain AntibodiesIBA 10/2021 - 01/2021
2	CalciumIBA 01/2021 - 01/2021
2	Bexarotene (LGD1069)FDA Link 01/2021 - 02/2016
2	peptide AIBA 01/2021 - 10/2015
2	Amyloidogenic ProteinsIBA 01/2020 - 01/2015
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020 - 11/2017
2	Cytotoxins (Cytolysins)IBA 01/2020 - 01/2019
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2019 - 05/2014
2	polyglutamineIBA 03/2017 - 01/2011
1	Thyroid HormonesIBA 12/2021
1	EpitopesIBA 10/2021
1	Biological ProductsIBA 10/2021
1	Small Heat-Shock ProteinsIBA 01/2021
1	Crystallins (Crystallin)IBA 01/2021
1	Amino Acids FDA Link 01/2021
1	N-Methylaspartate (NMDA)IBA 01/2021
1	AMPA Receptors (AMPA Receptor)IBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021
1	Unilamellar LiposomesIBA 11/2020
1	Lipid Bilayers (Lipid Bilayer)IBA 10/2020
1	thioflavin TIBA 01/2020
1	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 01/2020
1	Protein AggregatesIBA 12/2019
1	NeurotoxinsIBA 12/2019
1	Biomarkers (Surrogate Marker)IBA 11/2019
1	PrionsIBA 11/2019
1	Cyclic PeptidesIBA 10/2019
1	Cysteine (L-Cysteine)FDA Link 08/2019
1	HydrogelsIBA 01/2018
1	CholesterolIBA 01/2018
1	UbiquitinIBA 11/2017
1	Inosine Diphosphate (IDP)IBA 05/2016
1	Protein Isoforms (Isoforms)IBA 11/2015
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2015
1	Protein Kinase CIBA 01/2015
1	IronIBA 09/2014
1	SulfurIBA 09/2014
1	FrataxinIBA 09/2014
1	SulfonamidesIBA 01/2014
1	Alanine (L-Alanine)FDA Link 08/2011
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 04/2011
1	Ataxin-3IBA 01/2011
1	Congo RedIBA 09/2009
1	lacmoidIBA 09/2009
1	beta-SynucleinIBA 05/2008
1	Dopamine (Intropin)FDA LinkGeneric 01/2008

Therapy/Procedure

3	Therapeutics 10/2021 - 10/2018
1	Immunotherapy 01/2017